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How the flu virus spreads within cities

New insights into the local transmission of seasonal influenza may be valuable for planning interventions to combat the spread of respiratory diseases within cities, according to a new study.

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New therapy for flu may help in fight against COVID-19

A new therapy for influenza virus infections that may also prove effective against many other pathogenic virus infections, including HIV and COVID-19, has been developed by scientists. The team's...

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Hospital worker flu shots could mean fewer early deaths

Research shows that state laws promoting flu vaccinations for hospital workers can substantially reduce the number of influenza-related deaths.

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Asthma may heighten flu risk and cause dangerous mutations

A subtype of asthma in adults may cause higher susceptibility to influenza and could result in dangerous flu mutations. Animal studies have found that paucigranulocytic asthma (PGA) - a non-allergic...

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The original antigenic sin: How childhood infections could shape pandemics

A child's first influenza infection shapes their immunity to future airborne flu viruses - including emerging pandemic strains. But not all flu strains spur the same initial immune defense, according...

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Vaccine development software shows promise in influenza effort, could help...

A novel computer algorithm that could create a broadly reactive influenza vaccine for swine flu also offers a path toward a pan-influenza vaccine and possibly a pan-coronavirus vaccine as well,...

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Vaccine shows signs of protection against dozen-plus flu strains

A vaccine candidate has demonstrated promising signs of protection against more than a dozen swine flu strains -- and more than a leading, commercially available vaccine. Its success in experiments...

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Multiple factors synergistically drive socioeconomic disparities in flu burden

A comprehensive modeling study sheds new light on socioeconomic-based mechanisms that drive disparities in influenza burden across the U.S.

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Doctor communication key to pandemic vaccine adoption

People who talk with their doctors are more likely to get vaccinated during a pandemic, according to a study of evidence collected during the ''swine flu,'' the last pandemic to hit the U.S. before...

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Substantially higher burden of COVID-19 compared to flu, new research shows

A new study compares the impact of COVID-19 on patients and hospital resources versus the impact of influenza.

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Combination therapy may provide significant protection against lethal influenza

A significant proportion of hospitalized patients with influenza develop complications of acute respiratory distress syndrome. Investigators have found that treatment with an immune receptor blocker in...

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Flu shot associated with fewer, less severe COVID cases, study finds

People who received a flu shot last flu season were significantly less likely to test positive for a COVID-19 infection when the pandemic hit, according to a new study. And those who did test positive...

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A new treatment that might keep COVID-19 patients off the ventilator

A new treatment is among the first known to reduce the severity of acute respiratory distress syndrome caused by the flu in animals, according to a new study.

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How to predict severe influenza in hospitalized patients

Researchers have identified predictors of both severe disease and recovery in hospitalized influenza patients, finding that the immune system works in concert to fight influenza.

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COVID-19 is not influenza, but it offers lessons on beating it, say researchers

A study of the 2020 influenza figures from Canada, the United States, Australia and Brazil shows that there is a clear relationship between COVID-mitigation measures such as hand-washing, masking and...

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Lessons from the last pandemic point the way toward universal flu vaccines

A new study shows that during the last great pandemic -- 2009's H1N1 influenza pandemic -- people developed strong, effective immune responses to stable, conserved parts of the virus.

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Troubling birth findings show importance of timely flu vaccination

Poor timing of influenza vaccination campaigns in the semi-arid region of Brazil led to an increase in premature births, lower birth-weight babies and the need to deliver more babies by cesarean section.

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Cell-based influenza vaccine provides protection against the flu in children

A cell-based influenza vaccine has effectively provided protection against the flu in children and adolescents, according to a new study.

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New technique better assesses exposure of a population to a virus

Accurately assessing the exposure of a population to a particular virus is difficult because the tools for doing so do not account for the fact that many viruses comprise multiple circulating strains,...

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Repeated seasonal influenza vaccines also provide kids better protection...

Researchers have found that children who receive years of season-specific flu vaccines develop antibodies that also provide broader protection against new strains, including those capable of causing...

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COVID-19 mixed with flu increases risk of severe illness and death

Adults in hospital who have COVID-19 and the flu at the same time are at much greater risk of severe disease and death compared with patients who have COVID-19 alone or with other viruses, research...

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Universal flu vaccine candidate

Scientists have leveraged on a novel vaccine platform to deliver M2e to immune cells. This allowed them to prove that a single shot immunization containing M2e was able to trigger long-lasting immune...

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Global trial demonstrates some benefits of flu shots for heart failure patients

People with heart failure who received an annual flu shot had lower rates of pneumonia and hospitalization on a year-round basis and a reduction in major cardiovascular events during peak flu season,...

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AI can predict probability of COVID-19 vs flu based on symptoms

A new study highlights how clinicians can use artificial intelligence and seasonality to screen patients and identify the probability of COVID-19 prior to testing.

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Flu causes cardiac complications by directly infecting the heart

Researchers have shown for the first time in mice that heart problems associated with the flu are not caused by raging inflammation in the lungs, as has long been predicted. Instead, the electrical...

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No more flu for you? Discovery blocks influenza virus' replication in cells

Researchers have found a way to block one strain of the influenza virus from accessing a human protein it needs to replicate in cells. The discovery could lead to highly effective ways to treat the flu...

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New way to identify influenza A virus lights up when specific virus targets...

In order to quickly detect the presence of the influenza A virus, researchers developed a fluorogenic probe that could bind to the promoter region. A fluorogenic probe uses tiny molecules called...

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Universal influenza B vaccine induces broad, sustained protection, biomedical...

A new universal flu vaccine protects against influenza B viruses, offering broad defense against different strains and improved immune protection, according to a new study.

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Why some flu viruses cause more severe infections

Research uses computational modeling to try to understand the body's immune response to avian flu. His latest work finds that the levels of interferon may be responsible for its more severe...

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Old drug, new trick: Researchers find combining antiviral drugs and antibody...

Researchers have found a class of well-known antiviral drugs could be part of a one-two punch to treat seasonal influenza and prevent a flu pandemic when used in combination with antibody therapies.

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Universal flu vaccine protects against variants of both influenza A and B...

A new universal flu vaccine protects against diverse variants of both influenza A and B viruses in mice, according to a new study.

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Can the flu shot reduce your risk of stroke?

Getting an annual flu shot may be associated with a lower risk of stroke, according to a new study.

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U.S. unprepared for dangers posed by zoonotic diseases, new analysis concludes

The United States, the largest importer of wildlife in the world, is not prepared for future spread of animal-borne, or zoonotic, diseases due to gaps among governmental agencies designed to combat...

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First Nations populations at greater risk of severe flu, research finds

New research has found that First Nations populations around the world are significantly more likely to be hospitalized and die from influenza compared to non-Indigenous populations.

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Study explores how often children diagnosed with flu experience serious...

While the incidence of influenza-associated neuropsychiatric events in children in the United States is unknown, the controversy over the use of a common antiviral medication typically administered to...

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'Swine flu' strain has passed from humans to swine nearly 400 times since 2009

A new study of the strain of influenza A responsible for the 2009 H1N1 pandemic -- pdm09 -- shows that the virus has passed from humans to swine about 370 times since 2009, and subsequent circulation...

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Next-generation influenza B vaccines provide broad and long-lasting...

Recent preclinical results indicate novel next-generation vaccine candidates protect against multiple strains of influenza and last longer than vaccines currently in use.

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New type of antibody shows promise against multiple forms of flu virus

Researchers have identified a previously unrecognized class of antibodies -- immune system proteins that protect against disease -- that appear capable of neutralizing multiple forms of flu virus. The...

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Flu virus variants resistant to new antiviral drug candidate lose pathogenicity

Influenza A viruses with induced resistance to a new candidate antiviral drug were found to be impaired in cell culture and weakened in animals, according to a new study.

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Interactions between flu subtypes predict epidemic severity more than virus...

Researchers have shed new light on how viral evolution, population immunity, and the co-circulation of other flu viruses shape seasonal flu epidemics.

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Flu vaccines were effective in 2022-2023 flu season, studies find

The prospect of the worrisome triple threat of COVID, RSV and flu was assuaged last year by the effectiveness of flu vaccines. Two recent studies from the Centers for Disease Control and Prevention's...

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How children's birthdays help show the best month for flu shots

First large-scale analysis of optimal timing for flu shots finds October is the best month for children to get vaccinated against influenza. Study of 800,000 pediatrician visits leverages links between...

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'Hexaplex' vaccine aims to boost flu protection

A research team has developed a recombinant protein flu vaccine candidate. It utilizes a nanoliposome vaccine platform that underwent phase 2 and phase 3 clinical trials in South Korea and the...

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Changes in flu circulation means U.S. likely to see vaccines move from...

U.S. flu vaccines are likely to move from quadrivalent to trivalent due to a change in circulating influenza viruses, according to a new paper.

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New antibodies target 'dark side' of influenza virus protein

Researchers have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored 'dark side' of the neuraminidase (NA) protein head. The...

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Newborn piglets serve as a model for studying influenza

Although prevention and treatment strategies are available for influenza, they are not sufficient for vulnerable populations such as young children and newborns. A team of researchers has studied...

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